"Systematic study of IgG4-autoimmune diseases to develop new treatment strategies (IgG4-TREAT)" titled Horizon Europe Marie Skłodowska-Curie Actions (MSCA) project
The "Systematic study of IgG4-autoimmune diseases to develop new treatment strategies (IgG4-TREAT)" titled Horizon Europe Marie Skłodowska-Curie Actions (MSCA) project was found to be eligible for funding under the Horizon Europe Marie Skłodowska-Curie Actions (MSCA). Assoc. Prof. Dr. Vuslat Yılmaz, a faculty member of the Department of Neuroscience at Aziz Sancar Experimental Medicine Research Institute, will serve as the principal investigator.
Project Title: Systematic study of IgG4-autoimmune diseases to develop new treatment strategies (IgG4-TREAT)
Project Duration: 01.09.2023 - 01.09.2027
Budget: Total: 2.626.812,00 €, Istanbul University: 219.168,00 €
Partners:
- MEDIZINISCHE UNIVERSITAET WIEN (coordinator) (Austria)
- INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (France)
- UNIVERSITATSKLINIKUM SCHLESWIG-HOLSTEIN (Germany)
- ACADEMISCH ZIEKENHUIS LEIDEN (Netherlands)
- Stichting Sanquin Bloedvoorziening (Netherlands)
- CHARITE - UNIVERSITAETSMEDIZIN BERLIN (Germany)
- UNIVERSITEIT MAASTRICHT (Netherlands)
- TZARTOS - DIAGNOSIS & RESEARCH IN NEUROIMMUNOLOGY MEDICAL LIMITED LIABILITY COMPANY (Greece)
- Istanbul Universitesi (Türkiye)
Summary:
The project aims to investigate the cells, molecules, and mechanisms involved in producing pathogenic IgG4 autoantibodies using state-of-the-art cellular and molecular biology methods through a multi-omic approach. In this project, a new immunoadsorption-based treatment targeting emergency treatment for all IgG4-AID patients will be developed using a novel humanized IgG4-AID mouse model. The designed university-based and interdisciplinary research-based innovative training program will integrate academia and non-academic sectors with cutting-edge web-based training. Thus, the training aims to produce a new generation of experts in IgG4 AID research with the following characteristics:
1) Highly employable in both academia and industry, focusing on innovative multidisciplinary research aimed at biomedical product development.
2) Competent researchers with digital skills and awareness of gender equality and diversity; capable of addressing current and future global issues such as climate change, social inequalities, and emerging infectious diseases in innovative research.
Please click on the detailed information about the project.